SECRET SECRET WARS #1 by Matthew Allison

From Wikipedia:

Plot summary

Plot setup

A cosmic entity called the Beyonder observes the mainstream Marvel universe. Fascinated by the presence of superheroes on Earth and their potential, this entity chooses a group of both heroes and supervillains and teleports characters against their will to "Battleworld", a planet created by the Beyonder in a distant galaxy. This world has also been stocked with alien weapons and technology. The Beyonder then declares: "I am from beyond! Slay your enemies and all that you desire shall be yours! Nothing you dream of is impossible for me to accomplish!"

Soon realizing that the nobody he's chosen is going to slay diddly dunkus the Beyonder gathers a second group of heroes and villains who quite frankly have much less to lose. These C-listers are dropped 

on the opposite side of "Battleworld" where they are given massive amounts of recreational drugs and alcohol and are told: "I am from beyond! Slay anybody and I will give you a thousand dollars...and more 

drugs!"

Plot conflict

The heroes include Puck, Man-Thing, Karnak, Rom, Whizzer, The Thunderiders, aka Team America (Cowboy, Honcho, R.U. Ready, Wolf, and Wrench), Captain Ultra, and Son of Satan. Turner D Century is featured as a hero but immediately becomes non-aligned when everyone questions his presence. Everyone.

The villains include Blastaar, Doctor Demonicus, Plantman, Orca, Flag Smasher, Man-Ape, Armadillo, Moonstone, Black Talon, Texas Twister, and Karkas. The microcosmic entity Psycho-Man also appears as a villain who immediately becomes a non-aligned entity as he soon begins to mess with everyone's emotions via his control box. At one point in the series he forces all of the combatants to "hug it out".

The first hero to die is Honcho in issue 6. The Beyonder becomes increasingly frustrated as the heroes and villains begin to bond rather than destroy each other and so he cuts off their cocaine supply and refuses to give it back until someone is dead. As a sacrifice Honcho is strangled by his partner Wolf, much to the shock and dismay of his counterparts. However, Psycho-Man emotionally manipulates the rest of the team into having a kegger in Honcho's honor. In issue 7 Captain Ultra dies when he slips down a canyon face while peeing.